Ming-Hu Han Lab

1.Emily M Teichman, Jianping Hu, Hsiao-yun Lin, Rachel L Fisher-Foye, Anthony Blando, Xiaoping Hu, H Ümit Kaniskan, Sarah E Montgomery, Min Cai, Lyonna F Parise, Jun Wang, Scott J Russo, Ming-Hu Han, Jian Jin, Carole Morel. Design and validation of novel brain-penetrant HCN channel inhibitors to ameliorate social stress-induced susceptible phenotype，Molecular Psychiatry, Apr 8; 1-14
2. Laurel S Morris, Sara Costi, Sara Hameed, Katherine A Collins, Emily R Stern, Avijit Chowdhury, Carole Morel, Ramiro Salas, Dan V Iosifescu, Ming-Hu Han, Sanjay J Mathew, James W Murrough. Effects of KCNQ potassium channel modulation on ventral tegmental area activity and connectivity in individuals with depression and anhedonia, Molecular Psychiatry, 2025 Mar 25; 1-9
3. Min Cai, Yingbo Zhu, Mary Regis Shanley, Carole Morel, Stacy M Ku, Hongxing Zhang, Yuan Shen, Allyson K Friedman, Ming-Hu Han. HCN channel inhibitor induces ketamine-like rapid and sustained antidepressant effects in chronic social defeat stress model, Neurobiology of Stress, 2023 Sep 1; 26, 100565
4. Di Wang, Xiangyu Pan, Yu Zhou, Zifeng Wu, Kunpeng Ren, Hanyu Liu, Chaoli Huang, Yumei Yu, Teng He, Xiao Zhang, Ling Yang, Hongxing Zhang, Ming-Hu Han, Cunming Liu, Jun-Li Cao, Chun Yang. Lateral septum-lateral hypothalamus circuit dysfunction in comorbid pain and anxiety, Molecular Psychiatry, 2023 Jan 16; 28 (3), 1090-1100
5. Yi Han, Lin Ai, Lingzhen Song, Yu Zhou, Dandan Chen, Sha Sha, Ran Ji, Qize Li, Qingyang Bu, Xiangyu Pan, Xiaojing Zhai, Mengqiao Cui, Jiawen Duan, Junxia Yang, Dipesh Chaudhury, Ankang Hu, He Liu, Ming-Hu Han, Jun-Li Cao, Hongxing Zhang. Midbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice. Nature Communications, 2024 Jun 10; 15 (1), 4947
6. Carole Morel, Sarah E Montgomery, Long Li, Romain Durand-de Cuttoli, Emily M Teichman, Barbara Juarez, Nikos Tzavaras, Stacy M Ku, Meghan E Flanigan, Min Cai, Jessica J Walsh, Scott J Russo, Eric J Nestler, Erin S Calipari, Allyson K Friedman, Ming-Hu Han. Midbrain projection to the basolateral amygdala encodes anxiety-like but not depression-like behaviors, Nature Communications, 2022 Mar 22; 13 (1), 1532
7. Eric M Parise, Lyonna F Parise, Omar K Sial, Astrid M Cardona-Acosta, Trevonn M Gyles, Barbara Juarez, Dipesh Chaudhury, Ming-Hu Han, Eric J Nestler, Carlos A Bolaños-Guzmán. The resilient phenotype induced by prophylactic ketamine exposure during adolescence is mediated by the ventral tegmental area–nucleus accumbens pathway, Biological Psychiatry, 2021 Oct 1; 90 (7), 482-493
8. Sara Costi, Laurel S Morris, Katherine A Kirkwood, Megan Hoch, Morgan Corniquel, Brittany Vo-Le, Tabish Iqbal, Nisha Chadha, Diego A Pizzagalli, Alexis Whitton, Laura Bevilacqua, Manish K Jha, Stefan Ursu, Alan C Swann, Katherine A Collins, Ramiro Salas, Emilia Bagiella, Michael K Parides, Emily R Stern, Dan V Iosifescu, Ming-Hu Han, Sanjay J Mathew, James W Murrough. Impact of the KCNQ2/3 channel opener ezogabine on reward circuit activity and clinical symptoms in depression: results from a randomized controlled trial, American Journal of Psychiatry, 2021 May 1; 178 (5), 437-446
9. Hongxing Zhang, Dipesh Chaudhury, Alexander R Nectow, Allyson K Friedman, Song Zhang, Barbara Juarez, He Liu, Madeline L Pfau, Hossein Aleyasin, Cheng Jiang, Marshall Crumiller, Erin S Calipari, Stacy M Ku, Carole Morel, Nikos Tzavaras, Sarah E Montgomery, Michelle He, Stephen R Salton, Scott J Russo, Eric J Nestler, Jeffrey M Friedman, Jun-Li Cao, Ming-Hu Han. α1-and β3-adrenergic receptor–mediated mesolimbic homeostatic plasticity confers resilience to social stress in susceptible mice, Biological Psychiatry, 2019 Feb 1; 85 (3), 226-236
10. Allyson K Friedman, Barbara Juarez, Stacy M Ku, Hongxing Zhang, Rhodora C Calizo, Jessica J Walsh, Dipesh Chaudhury, Song Zhang, Angel Hawkins, David M Dietz, James W Murrough, Maria Ribadeneira, Erik H Wong, Rachael L Neve, Ming-Hu Han. KCNQ channel openers reverse depressive symptoms via an active resilience mechanism, Nature Communications, 2016 May 24; 11671
11. Friedman AK, Walsh JJ, Juarez B, Ku SM, Chaudhury D, Wang J, Li X, Dietz DM, Pan N, Vialou VF, Neve RL, Yue Z, Han MH. Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience. Science, 2014 Apr 18;344(6181):313-9.
12. Chaudhury D, Walsh JJ, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai HC, Pomeranz L, Christoffel D, Nectow AR, Ekstrand M, Domingos A, Mazie-Robison M, Mouzon E, Lobo MK, Neve RL, Friedman JM, Russo SJ, Deisseroth K, Nestler EJ. Han MH.Rapid regulation of depression-like behaviors by control of midbrain dopamine neurons. Nature, 2013 Jan 24;493(7433):532-6. [Chaudhury and Walsh contributed equally]
13. Lobo MK, Covington III HE, Chaudhury D, Friedman AK, Sun HS, Damez-Werno D, Dietz D, Zaman S, Koo JW, Kennedy PJ, Mouzon E, Mogri M, Neve RL, Deisseroth K, Han MH, Nestler EJ. Cell type specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science, 2010 Oct 15;330(6002):385-90.
14. Krishnan V*, Han MH*, Graham DL, Berton O, Renthal W, Russo SJ, LaPlant Q, GrahamA, Lutter M, Lagace DC, Ghose S, Reister R, Tannous P, Green TA, Neve RL, Chakravarty S, Kumar A, Eisch AJ, Self DW, Lee FS, Tamminga C, Cooper DC, Gershenfeld HK and Nestler EJ. Molecular Adaptations Underlying Susceptibility and Resistance to Social Defeat in Brain Reward Regions. Cell, 2007 Oct 19; 131(2):391-404
15. Cao JL, Covington III HE, Friedman AK, Wilkinson MB, Walsh JJ, Cooper DC, Nestler EJ, Han MH. Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action. Journal of Neuroscience, 2010 Dec 8;30(49):16453-8.
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